Self-sensing in Bacillus subtilis quorum-sensing systems
نویسندگان
چکیده
منابع مشابه
Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.
The ComX pheromone is an extracellular signaling molecule that stimulates natural competence in response to crowding in the gram-positive bacterium Bacillus subtilis. The pheromone is formed by isoprenylation of an inactive precursor peptide, but its precise structure is not known. Here we report the structure of the ComX pheromone, showing that addition of a geranyl group to a tryptophan resid...
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Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...
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The comQXPA locus of Bacillus subtilis encodes a quorum sensing (QS) system typical of Gram positive bacteria. It encodes four proteins, the ComQ isoprenyl transferase, the ComX pre-peptide signal, the ComP histidine kinase, and the ComA response regulator. These are encoded by four adjacent genes all situated on the same chromosome strand. Here we present results of a comprehensive census of c...
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AIM Engineering of Rap-Phr quorum-sensing systems of Bacillus subtilis and subsequent evaluation of the transcription of the aprE gene, encoding a major extracellular alkaline protease. METHODS AND RESULTS Addition of synthetic Phr pentapeptides to the growth medium, or overproduction of pre-Phr peptides, slightly improved the transcription of the aprE gene in B. subtilis. Disruption of certa...
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This paper continues the investigation of population P systems model [F. Bernardini, M. Gheorghe, Population P systems, Journal of Universal Computer Science 10 (5) (2004) 509–539] by considering bacterium quorum sensing (QS) phenomena as the basis of the new approach. A new computational model called QS P system is introduced. It is proved that QS P systems are able to simulate counter machine...
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ژورنال
عنوان ژورنال: Nature Microbiology
سال: 2017
ISSN: 2058-5276
DOI: 10.1038/s41564-017-0044-z